Using Electron Tunneling for Direct Sequencing of DNA

نویسندگان

  • John Lund
  • Ranjana Mehta
  • Maryam Rahimi
  • Babak A. Parviz
چکیده

We report an electronic method that has the capacity to directly read bases without any chemical manipulation or labeling of DNA. Our method consists of stretching DNA on a conductive substrate which can then be analyzed using inelastic electron tunneling spectroscopy (IETS). We have developed techniques to stretch DNA molecules on conductive substrates and have experimentally validated our method using a scanning tunneling microscope (STM) in identification of monolayers of oligonucleotides on gold substrates..

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تاریخ انتشار 2007